Missouri State Route 36 is a major east-west highway that spans approximately 245 miles across the northern part of Missouri. It connects the cities of St. Joseph in the west to Hannibal in the east, serving as a vital transportation route for both local and through traffic. The highway passes through several counties, including Andrew, Nodaway, and Marion. It intersects with other significant routes, such as U.S. Route 63 and Interstate 35, facilitating access to various communities and attractions along its path.