Michael I of Epirus was a Byzantine noble who ruled as the Despot of Epirus from 1224 to 1266. He was a member of the Angelus family and played a significant role in the political landscape of the Byzantine Empire during the 13th century. His reign was marked by efforts to expand his territory and strengthen his power in the region. Michael I is best known for his conflict with the Latin Empire and his attempts to restore Byzantine authority in the area. He established alliances with neighboring states and sought to reclaim lost lands, contributing to the complex history of Medieval Greece and the struggle for dominance in the Balkans.