A metabotropic receptor is a type of receptor found on the surface of cells that responds to neurotransmitters. Unlike ionotropic receptors, which directly open ion channels, metabotropic receptors work through a series of biochemical events inside the cell. When a neurotransmitter binds to a metabotropic receptor, it activates a G-protein, which then triggers various signaling pathways that can lead to changes in cell function. These receptors play a crucial role in modulating neuronal activity and are involved in many processes, including mood regulation and sensory perception. They are important in the functioning of the central nervous system and are linked to various conditions, such as depression and schizophrenia.