Merkel cells are specialized cells found in the skin, primarily in the epidermis. They are located near the base of the epidermis and are associated with sensory nerve endings. These cells play a crucial role in the sense of touch, helping to detect light pressure and texture. These cells are named after the German anatomist Friedrich Merkel, who first described them in the 19th century. Merkel cells contain dense-core granules and release neurotransmitters in response to mechanical stimuli, facilitating communication with sensory neurons. Their function is essential for the tactile sensitivity of the skin.