"Me and Earl and the Dying Girl" is a coming-of-age novel by Jesse Andrews that follows the story of Greg Gaines, a high school student who prefers to stay under the radar. His life takes a turn when his mother insists he befriends Rachel, a classmate diagnosed with leukemia. As Greg navigates his complicated feelings about friendship and mortality, he enlists his filmmaking partner, Earl, to create a film for Rachel. The story explores themes of friendship, love, and the impact of illness, all while maintaining a humorous and relatable tone.