"Masters of Sex" is a television series that aired from 2013 to 2016, based on the biography of Dr. William Masters and Virginia Johnson. The show explores their groundbreaking research on human sexuality in the 1950s and 1960s, highlighting their professional and personal relationship as they study sexual response and behavior. The series delves into the social and cultural attitudes towards sex during that era, showcasing the challenges they faced in their work. It also features a diverse cast, including Lizzy Caplan as Virginia Johnson and Michael Sheen as William Masters, bringing to life the complexities of their pioneering studies.