The Marqueses de Alcañices is a Spanish noble title that originated in the late 15th century. It was granted to the family of the Pérez de Guzmán lineage, specifically to Juan de Pérez de Guzmán, who played a significant role in the Reconquista. The title is associated with the town of Alcañices, located in the province of Zamora, in the region of Castile and León. The title has been passed down through generations, often linked to various historical events and figures in Spanish nobility. The Marqueses de Alcañices have held significant influence in the region, contributing to local governance and culture throughout their history.