The Louisville, Evansville and St. Louis Railroad (LE&StL) was a regional railroad in the United States that operated primarily in the late 19th and early 20th centuries. It connected the cities of Louisville, Evansville, and St. Louis, facilitating the movement of goods and passengers across the Midwest. The railroad played a significant role in the economic development of the areas it served. Founded in 1880, the LE&StL expanded its network through various acquisitions and mergers. It became part of the Illinois Central Railroad in 1925, which helped integrate its services into a larger transportation system. The railroad's legacy continues to influence regional rail operations today.