Long-chain fatty acid oxidation disorders are a group of genetic conditions that affect the body's ability to break down long-chain fatty acids for energy. These disorders occur when specific enzymes needed for fatty acid metabolism are deficient or absent, leading to the accumulation of fatty acids in the body. This can result in various health issues, including muscle weakness, hypoglycemia, and liver problems. Individuals with these disorders may experience symptoms during periods of fasting or illness when the body relies on fat for energy. Early diagnosis and management are crucial to prevent complications. Treatment often includes dietary changes and supplementation to help manage symptoms and support energy needs.