Lafora bodies are abnormal, insoluble aggregates of glycogen that accumulate in the cells of individuals with Lafora disease, a rare genetic disorder. These structures are primarily found in the brain and liver and are associated with neurodegeneration and seizures. The presence of Lafora bodies is a key diagnostic feature of Lafora disease, which typically manifests in late childhood or early adolescence. This condition is caused by mutations in specific genes, leading to impaired glycogen metabolism and the formation of these distinctive bodies within cells.