The cast of Kyunki Saas Bhi Kabhi Bahu Thi includes several prominent actors who contributed to the show's popularity. The lead role of Tulsi Virani was played by Smriti Irani, while Sakshi Tanwar portrayed Parvati. Other notable cast members included Ronit Roy as Mihir Virani and Hiten Tejwani as Karan Virani. The series also featured a strong supporting cast, including Gauri Pradhan as Nandini and Kiran Karmakar as Karan's brother. The ensemble cast helped create a rich narrative that resonated with audiences, making the show a significant part of Indian television history.