Jesse Chisholm was a notable American frontiersman and trader in the 19th century, best known for his role in the development of the Chisholm Trail. Born in 1805, he was of mixed Cherokee and European descent and became a prominent figure in the cattle trade, facilitating the movement of cattle from Texas to markets in the northern United States. Chisholm's contributions extended beyond trade; he also served as a guide and interpreter for various expeditions. His legacy is commemorated through the Chisholm Trail, which became a vital route for cattle drives and significantly impacted the economy of the American West.