The Interleukin-2 Receptor Gamma Chain, often abbreviated as IL-2Rγ, is a protein that plays a crucial role in the immune system. It is a component of several interleukin receptors, including those for IL-2, IL-4, IL-7, IL-9, and IL-15. This chain is essential for the signaling pathways that activate immune cells, particularly T cells and B cells, which are vital for the body's defense against infections. Mutations or deficiencies in the IL-2Rγ gene can lead to severe combined immunodeficiency (SCID), a condition that severely impairs the immune response. This highlights the importance of the gamma chain in maintaining a functional immune system. Understanding the role of IL-2Rγ can aid in developing therapies for immune-related disorders and improving treatments for various diseases.