"Inspector Gadget's Greatest Gadgets" showcases the iconic tools used by the clumsy yet lovable detective, Inspector Gadget. His gadgets include a variety of whimsical devices, such as extendable arms, helicopter hats, and roller skates, which help him solve crimes and chase villains. The show features Dr. Claw, the main antagonist, who constantly devises plans to thwart Gadget. Despite his bumbling nature, Gadget often succeeds thanks to his gadgets and the assistance of his niece, Penny, and her dog, Brain. Together, they navigate challenges and outsmart their foes in a lighthearted, comedic manner.