Illinois Route 49 is a state highway located in the east-central part of Illinois. It runs approximately 50 miles, connecting the towns of Mattoon and Watseka. The route primarily serves as a north-south corridor, facilitating local and regional travel. The highway passes through several communities, including Charleston and Tuscola. It intersects with other major roads, enhancing accessibility to nearby areas. Illinois Route 49 is an important route for both residents and businesses, contributing to the local economy and transportation network.