IL2RB, or Interleukin-2 receptor beta, is a protein that plays a crucial role in the immune system. It is part of the receptor complex for interleukin-2 (IL-2), a cytokine that helps regulate the growth and activity of T cells, which are essential for immune responses. IL2RB is primarily expressed on the surface of T cells and B cells, facilitating their activation and proliferation in response to immune challenges. The IL2RB gene is located on chromosome 22 and is essential for the proper functioning of the immune system. Mutations or deficiencies in IL2RB can lead to immune disorders, such as severe combined immunodeficiency (SCID). Understanding IL2RB's function is important for developing therapies for autoimmune diseases and improving immune responses in various medical conditions.