Hugo de Rune is a fictional character from the video game series A Plague Tale, created by Asobo Studio. He is the younger brother of the main protagonist, Amicia de Rune, and plays a crucial role in the story, which revolves around their struggle to survive in a plague-ridden world. Hugo suffers from a mysterious illness that grants him unique abilities, making him both a target and a key figure in the narrative. The bond between Hugo and Amicia drives the emotional core of the game, highlighting themes of family, protection, and resilience amidst adversity.