The "House of Mystery" is a fictional location in the DC Comics universe, primarily associated with the horror genre. It first appeared in 1951 and serves as a supernatural setting where various stories unfold, often featuring themes of mystery and the unknown. The house itself is known for its shifting architecture and the strange occurrences that take place within its walls. The house is often linked to characters like Cain, who serves as its caretaker and storyteller. It has been featured in various comic book series, including its own title, where readers encounter eerie tales and unexpected twists. The "House of Mystery" remains a significant part of DC's horror storytelling tradition.