The House of Gonzaga was an influential Italian noble family that ruled the city of Mantua from the 14th to the 18th centuries. They rose to power through strategic marriages and military alliances, becoming prominent patrons of the arts and culture during the Renaissance. The Gonzagas are known for their contributions to architecture and the arts, commissioning works from famous artists like Andrea Mantegna and Giulio Romano. Their legacy includes the stunning Palazzo Ducale in Mantua, which showcases their wealth and cultural significance in Italy's history.