House Harkonnen is one of the Great Houses in the science fiction universe of Dune, created by Frank Herbert. Known for their ruthless and oppressive tactics, they control the desert planet of Giedi Prime and are infamous for their exploitation of the spice melange, a valuable resource in the galaxy. The Harkonnens are led by the cunning and cruel Baron Vladimir Harkonnen, who seeks power and wealth at any cost. Their rivalry with House Atreides is central to the story, highlighting themes of betrayal, ambition, and the struggle for control over the spice trade.