The Hepatitis B vaccine is a safe and effective immunization that protects against the Hepatitis B virus, which can cause serious liver disease. The vaccine is typically given in a series of three or four shots, starting at birth or during early childhood. Receiving the Hepatitis B vaccine helps prevent the spread of the virus, which can be transmitted through contact with infected blood or bodily fluids. Vaccination is especially important for individuals at higher risk, such as healthcare workers and those with multiple sexual partners.