Harrison's Principles of Internal Medicine is a comprehensive medical textbook widely used by healthcare professionals and students. First published in 1950, it covers a broad range of topics related to internal medicine, including diagnosis, treatment, and prevention of diseases. The book is known for its evidence-based approach and detailed explanations, making it a valuable resource for understanding complex medical conditions. The textbook is organized into sections that address various organ systems and diseases, providing in-depth information on pathophysiology, clinical features, and management strategies. Harrison's is often regarded as a cornerstone in medical education and is frequently updated to reflect the latest research and clinical practices.