The Hantzsch Reaction is a chemical reaction that synthesizes dihydropyridines, which are important compounds in organic chemistry. This reaction typically involves the condensation of an aldehyde, a β-ketoester, and ammonia or an amine, leading to the formation of a 1,4-dihydropyridine structure. This reaction is significant due to its utility in creating various pharmaceuticals and biologically active compounds. The Hantzsch Dihydropyridine derivatives produced are often used in the development of calcium channel blockers and other medicinal agents, highlighting the reaction's importance in drug discovery and development.