"Hand Shakers" is an anime series that follows a group of individuals known as Hand Shakers, who can summon powerful weapons called Nexus. These characters engage in battles to prove their strength and resolve, with each fight revealing more about their personal struggles and motivations. The series combines action with elements of fantasy and psychological themes. The story centers around Tazuna and Koyori, two main characters who form a partnership as they navigate the challenges of the Hand Shakers' world. As they face various opponents, they uncover the deeper connections between their abilities and the mysterious organization behind the battles.