An HTTP Response is a message sent by a server to a client after receiving an HTTP Request. It contains information about the result of the request, including a status code, headers, and the requested content. The status code indicates whether the request was successful, encountered an error, or requires further action. The response headers provide additional context, such as content type and caching instructions. The body of the response may include the requested data, like a web page or an image. Together, these elements help the client understand the outcome of its request and how to proceed.