HIF-2α, or Hypoxia-Inducible Factor 2 Alpha, is a protein that plays a crucial role in how cells respond to low oxygen levels, a condition known as hypoxia. It helps regulate various genes involved in processes like cell growth, metabolism, and blood vessel formation. By activating these genes, HIF-2α enables cells to adapt to oxygen scarcity, which is important in both normal physiology and disease states. In addition to its role in oxygen response, HIF-2α is also implicated in certain diseases, including cancer. Tumors often experience low oxygen levels, and HIF-2α can promote tumor growth and survival by enhancing blood supply and metabolic adaptation. Understanding HIF-2α's functions may lead to new therapeutic strategies for managing conditions related to hypoxia and cancer.