HECTD2 is a gene that encodes a protein involved in various cellular processes, including the regulation of gene expression and protein degradation. It belongs to the HECT family of E3 ubiquitin ligases, which play a crucial role in tagging proteins for degradation by the proteasome, a cellular structure responsible for breaking down unneeded or damaged proteins. The HECTD2 protein is particularly important in the development and functioning of the nervous system. Mutations in the HECTD2 gene have been linked to certain genetic disorders, highlighting its significance in maintaining cellular health and proper biological functions.