The Great Plague of London occurred in 1665-1666 and was one of the last major outbreaks of the bubonic plague in England. It is estimated that around 100,000 people, nearly a quarter of London's population, died from the disease. The plague was spread by fleas that lived on rats, and it caused symptoms such as fever, chills, and painful swellings. To control the outbreak, authorities implemented strict measures, including quarantining infected households and closing public places. The plague significantly impacted daily life, leading to fear and social disruption. The epidemic eventually subsided, but it left a lasting mark on the history of London.