The Great Plague was a devastating outbreak of the bubonic plague that struck Europe in the 17th century, particularly between 1665 and 1666. It is estimated that around 100,000 people in London died from the disease, which was spread by fleas on rats. The symptoms included fever, chills, and painful swellings called buboes, leading to a high mortality rate. During this time, many people fled the city to escape the illness, while others were quarantined. The Great Plague had a significant impact on society, leading to changes in public health measures and a greater understanding of disease transmission.