Granulomatous disease refers to a group of conditions characterized by the formation of granulomas, which are small clusters of immune cells that form in response to chronic inflammation. These granulomas can develop in various organs, including the lungs, liver, and skin, and may disrupt normal function. Common causes include infections, autoimmune diseases, and exposure to certain substances. One well-known example of granulomatous disease is sarcoidosis, which often affects the lungs and can cause symptoms like cough and shortness of breath. Other conditions, such as tuberculosis and Crohn's disease, can also lead to granuloma formation. Diagnosis typically involves imaging studies and biopsy to identify the granulomas and determine the underlying cause.