Grafton Depot is a historic train station located in Grafton, West Virginia. Built in the late 19th century, it served as a vital hub for the Baltimore and Ohio Railroad. The depot played a significant role in the transportation of goods and passengers, contributing to the growth of the local economy. Today, Grafton Depot is recognized for its architectural significance and is often visited by history enthusiasts. It has been preserved as a part of the Grafton National Cemetery area, showcasing the rich history of rail travel in the region and serving as a reminder of the importance of railroads in American history.