Glycogen Synthase is an essential enzyme responsible for the synthesis of glycogen, a stored form of glucose in the body. It catalyzes the addition of glucose units to a growing glycogen chain, primarily in the liver and muscle tissues. This process is crucial for maintaining energy reserves, especially during periods of fasting or intense physical activity. The activity of Glycogen Synthase is regulated by various hormones, including insulin and glucagon. When insulin levels are high, such as after a meal, glycogen synthesis is promoted, allowing excess glucose to be stored. Conversely, during fasting, glucagon signals the breakdown of glycogen to release glucose into the bloodstream.