Gibbs Free Energy is a thermodynamic quantity that helps predict whether a chemical reaction will occur spontaneously. It combines the system's enthalpy (total energy) and entropy (degree of disorder) to determine the energy available to do work at constant temperature and pressure. A negative change in Gibbs Free Energy indicates that a reaction can proceed spontaneously, while a positive change suggests it will not. The formula for Gibbs Free Energy is ΔG = ΔH - TΔS, where ΔG is the change in Gibbs Free Energy, ΔH is the change in enthalpy, T is the temperature in Kelvin, and ΔS is the change in entropy. Understanding this concept is crucial in fields like chemistry and biochemistry, as it helps scientists and engineers design efficient reactions and processes.