Gastrointestinal Stromal Tumors (GISTs) are a type of tumor that occurs in the digestive tract, most commonly in the stomach and small intestine. They arise from interstitial cells of Cajal or precursor cells, which are part of the gastrointestinal system. GISTs can vary in size and may be benign or malignant, often causing symptoms like abdominal pain, bleeding, or obstruction. These tumors are often associated with mutations in the KIT gene, which plays a role in cell growth. Treatment typically involves surgical removal of the tumor, and targeted therapies, such as imatinib, may be used for advanced cases. Early diagnosis is crucial for effective management.