Fructose-1,6-bisphosphatase is an important enzyme in the process of gluconeogenesis, which is the production of glucose from non-carbohydrate sources. It catalyzes the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate, effectively helping to regulate blood sugar levels. This enzyme is primarily found in the liver and kidneys, where it plays a crucial role in maintaining energy balance. The activity of fructose-1,6-bisphosphatase is influenced by various factors, including hormonal signals like insulin and glucagon. When energy is needed, glucagon stimulates the enzyme, promoting glucose production. Conversely, insulin inhibits its activity, helping to lower blood sugar levels after meals.