Fifty-Third Street is a major east-west thoroughfare located in Manhattan, New York City. It runs from the Hudson River in the west to the East River in the east, spanning several neighborhoods, including Midtown and Upper East Side. The street is known for its proximity to various cultural institutions, businesses, and residential areas. Along Fifty-Third Street, you can find notable landmarks such as the Museum of Modern Art and the Ed Sullivan Theater. The street is also home to numerous restaurants, shops, and offices, making it a bustling area for both locals and tourists.