Fibrinolysis is the biological process that breaks down fibrin, a protein involved in blood clotting. This process is essential for maintaining normal blood flow after a clot has formed to stop bleeding. Enzymes, primarily plasmin, play a crucial role in dissolving the fibrin mesh that stabilizes the clot, allowing for tissue repair and restoration of circulation. The fibrinolytic system is tightly regulated to prevent excessive clotting or bleeding. Plasminogen, an inactive precursor of plasmin, is converted into plasmin by various activators, including tissue plasminogen activator (tPA). This balance ensures that clots are removed when they are no longer needed, promoting healthy healing.