The ETS domain is a protein domain found in a variety of organisms, including humans. It is named after the E26 transformation-specific gene, which was first identified in a type of cancer. The ETS domain is known for its role in binding to DNA, influencing gene expression, and regulating various biological processes. Proteins containing the ETS domain are involved in critical functions such as cell growth, differentiation, and development. They play significant roles in processes like angiogenesis and neurogenesis, making them important in both normal physiology and disease states, including cancer.