EPCR, or Endothelial Protein C Receptor, is a protein found on the surface of endothelial cells, which line blood vessels. It plays a crucial role in the regulation of blood coagulation and inflammation by binding to protein C, a plasma protein that helps prevent excessive blood clotting. When protein C is activated, it can inhibit clot formation and promote the breakdown of clots, contributing to a balanced hemostatic process. EPCR also has a role in protecting tissues from damage during inflammatory responses, highlighting its importance in maintaining vascular health and preventing disorders related to blood clotting.