The Dukes of Infantado is a noble title in Spain, historically associated with the region of Guadalajara. The title was first granted in the 15th century to the powerful López de Mendoza family, who played a significant role in Spanish history. The dukedom has been linked to various political and military events throughout the centuries. The Dukes of Infantado have held significant estates and influence, particularly during the Spanish Golden Age. Their lineage includes notable figures in Spanish literature and politics, contributing to the cultural heritage of Spain. The title remains a symbol of aristocratic tradition in the country.