The Duke of Infantado is a noble title in Spain, historically associated with the House of Mendoza. Established in the late 15th century, it has been held by various members of the Mendoza family, who played significant roles in Spanish history, particularly during the Reconquista and the Spanish Empire. The title is linked to the region of Infantado, located in the province of Guadalajara. The dukes have often been influential in politics and culture, contributing to the arts and architecture, including the construction of notable buildings like the Palace of the Duke of Infantado in Guadalajara.