The Duke of Anjou is a title historically associated with the region of Anjou in France. It was held by various noble families, most notably the Plantagenets and the Valois. The title became significant during the Middle Ages, especially as it was linked to claims to the French throne. One of the most famous Dukes of Anjou was Henry III of France, who ruled in the late 16th century. The title has also been associated with various European royal houses, including the House of Bourbon, which played a crucial role in French history and politics.