A dopamine reuptake inhibitor (DRI) is a type of medication that prevents the reabsorption of dopamine, a neurotransmitter associated with pleasure and reward, back into the neurons. By blocking this reuptake process, DRIs increase the levels of dopamine in the brain, which can enhance mood and motivation. DRIs are often used to treat conditions such as depression, attention deficit hyperactivity disorder (ADHD), and Parkinson's disease. Common examples of DRIs include bupropion and methylphenidate. These medications can help improve symptoms by promoting better communication between nerve cells in the brain.