DOM Manipulation refers to the process of changing the structure, style, or content of a web page using JavaScript. The Document Object Model (DOM) represents the page as a tree of objects, where each element, attribute, and text is a node. By accessing these nodes, developers can add, remove, or modify elements dynamically, allowing for interactive and responsive web applications. Common tasks in DOM Manipulation include changing the text of a HTML element, altering its style, or responding to user events like clicks. This capability enhances user experience by enabling real-time updates without needing to reload the entire page.