The D-100 Highway, also known as the E-5, is a major roadway in Turkey that connects the city of Istanbul to Ankara. It serves as a vital transportation route for both local and long-distance travel, facilitating the movement of goods and people across the country. This highway spans approximately 1,200 kilometers and passes through several important cities, including Bursa and Eskişehir. The D-100 is crucial for economic activities, as it links various industrial regions and provides access to numerous commercial centers along its route.