Cyrus "The Virus" Grissom is a fictional character from the 1997 action film Con Air, directed by Simon West. Portrayed by actor John Malkovich, Grissom is a cunning and manipulative criminal mastermind who leads a group of dangerous convicts during a transport flight gone awry. His character is known for his intelligence and ruthlessness, making him a formidable antagonist. In the film, Grissom's ultimate goal is to escape from law enforcement and seize control of the plane. He is characterized by his distinctive appearance and unsettling demeanor, which contribute to his reputation as a notorious criminal. Grissom's interactions with other characters, including protagonist Cameron Poe, highlight his strategic thinking and willingness to resort to violence to achieve his objectives.