Creutzfeldt-Jakob disease (CJD) is a rare and degenerative brain disorder caused by abnormal proteins called prions. These prions lead to the progressive deterioration of brain tissue, resulting in severe neurological symptoms. CJD can occur sporadically, be inherited, or arise from exposure to infected tissue. Symptoms of CJD typically include rapid cognitive decline, memory loss, personality changes, and coordination problems. The disease progresses quickly, often leading to severe disability and death within months to a few years after onset. There is currently no cure or effective treatment for CJD, making it a serious public health concern.