Cochliomyia hominivorax, commonly known as the primary screwworm, is a species of fly that primarily affects warm-blooded animals, including humans. The larvae of this fly are known for infesting wounds, leading to severe tissue damage and infections. This species is particularly notorious in livestock, causing significant economic losses in agriculture. The primary screwworm is native to the Americas but has been eradicated from the United States through extensive control programs. It is a major concern in tropical regions, where it can thrive and pose risks to both animal and human health. Effective management strategies are essential to prevent outbreaks.