Missouri is home to several notable cities, each with its unique characteristics. The largest city, Kansas City, is known for its jazz music, barbecue, and vibrant arts scene. St. Louis, another major city, is famous for the iconic Gateway Arch and its rich history in the brewing industry. Other cities like Springfield and Columbia offer a mix of cultural attractions and educational institutions. Springfield is recognized as the birthplace of Route 66, while Columbia is home to the University of Missouri, contributing to its lively atmosphere. Each city plays a vital role in the state's economy and culture.