A Cholinergic Crisis occurs when there is an excess of the neurotransmitter acetylcholine in the body, often due to the inhibition of the enzyme acetylcholinesterase. This can lead to overstimulation of the cholinergic receptors, resulting in symptoms such as muscle weakness, excessive salivation, and respiratory distress. It is commonly associated with conditions like myasthenia gravis or exposure to certain toxins. Treatment typically involves the administration of anticholinergic medications, which help to counteract the effects of excess acetylcholine. In severe cases, supportive care may be necessary, including respiratory support and monitoring of vital signs. Prompt recognition and intervention are crucial to prevent complications.